The difference between stateless session beans and message-driven beans are:

1. The most visible difference between message-driven beans and session beans is that clients do not access message-driven beans through interfaces.
2. Message driven bean has only a bean class whereas stateless session bean can have an interface and a bean class.
3. Clients cannot interact with message-driven bean directly, they can interact indirectly by sending messages to JMS Queue or Topic.
4. Message-driven beans process multiple JMS messages asynchronously, rather than processing a serialized sequence of method calls like session beans.